Response to "Glioma resection and tumor recurrence: back to Semmelweis".
نویسندگان
چکیده
We would like to thank David Ratel, Boudewijn van der Sanden, and Didier Wion for their comments, and to further develop their interesting hypothesis. Compelling evidence demonstrates that radiotherapy, as well as surgery, improves glioblastoma survival. However, in recent years certain reports have highlighted the contradictory effect of radiotherapy, which also stimulates the expression of inflammatory mediators.1–3 These cytokines can increase the ability of cancer cells to infiltrate the brain. In that case, do we have to abandon glioma surgery and radiotherapy? Certainly not, but we have to seriously take into account these paradoxical effects of brain surgery and radiotherapy. Local therapy applied after tumor resection in the surgical cavity would be a breakthrough strategy if in place of cytotoxic drugs,4,5 molecules inhibiting inflammatory and astrocytic reactions could be released. In this regard, a novel approach could be developed at the crossroads of regenerative medicine (brain repair) and neuro-oncology.
منابع مشابه
A phase I/II clinical trial for adult recurrent glioma using 131i-tm-601, an iodinated peptide derived from scorpion venom
131I-TM-601 is a 36-amino acid peptide, called chlorotoxin (TM-601), derived from scorpion venom labeled with I-131. TM-601 binds a receptor on the surface of tumor cells, and not on normal cells. A single dose of 131I-TM-601 administered intracranially to human xenografted mouse models of glioma has been shown to extend survival up to 269% in multiple studies. 131I-TM-601 is in a multi-center ...
متن کاملA phase I/II clinical trial for adult recurrent glioma using 131i-tm-601, an iodinated peptide derived from scorpion venom
131I-TM-601 is a 36-amino acid peptide, called chlorotoxin (TM-601), derived from scorpion venom labeled with I-131. TM-601 binds a receptor on the surface of tumor cells, and not on normal cells. A single dose of 131I-TM-601 administered intracranially to human xenografted mouse models of glioma has been shown to extend survival up to 269% in multiple studies. 131I-TM-601 is in a multi-center ...
متن کاملبررسی موارد و عوامل مؤثر در عود مننژیوم مغزی طی یک دوره 20 ساله
Background: Meningiomas are common benign tumors of the brain. Meningioma patients have optimal functional recovery after surgical removal of their tumors. Some patients experience recurrence months or years after surgical resection. In this study, we try to determine the prevalence of recurrent meningioma and the correlation between recurrence and certain factors. Methods: This retrospective ...
متن کاملAggressive angiomyxoma of the vulva: a case report
Background: Aggressive angiomyxoma is a rare mesenchymal tumor with extensive local invasion. It often presents with a lump in the perineal area and pelvic. Since it often does not involve adjacent organs such as the urethra and anus, does not cause obstructive symptoms. Its incidence is 6 times higher in women than men. This tumor grows slowly and has a slight tendency to metastasize. However,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Neuro-oncology
دوره 18 12 شماره
صفحات -
تاریخ انتشار 2016